Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells

Extracellular histones have been reported to aggravate different pathophysiological processes by increasing vascular permeability, coagulopathy, and inflammation. In the present study, we elucidate how extracellular histones (10–100 µg/mL) concentration dependently increase cytosolic reactive oxygen...

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Detalles Bibliográficos
Autores principales: Pérez-Cremades, Daniel, Bueno-Betí, Carlos, García-Giménez, José Luis, Ibañez-Cabellos, José Santiago, Pallardó, Federico V., Hermenegildo, Carlos, Novella, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300178/
https://www.ncbi.nlm.nih.gov/pubmed/36464762
http://dx.doi.org/10.1007/s13105-022-00935-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300178/
https://www.ncbi.nlm.nih.gov/pubmed/36464762
http://dx.doi.org/10.1007/s13105-022-00935-z

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