Cargando…

Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells

Extracellular histones have been reported to aggravate different pathophysiological processes by increasing vascular permeability, coagulopathy, and inflammation. In the present study, we elucidate how extracellular histones (10–100 µg/mL) concentration dependently increase cytosolic reactive oxygen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pérez-Cremades, Daniel, Bueno-Betí, Carlos, García-Giménez, José Luis, Ibañez-Cabellos, José Santiago, Pallardó, Federico V., Hermenegildo, Carlos, Novella, Susana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300178/ https://www.ncbi.nlm.nih.gov/pubmed/36464762 http://dx.doi.org/10.1007/s13105-022-00935-z

Ejemplares similares

Extracellular histones disarrange vasoactive mediators release through a COX‐NOS interaction in human endothelial cells
por: Pérez‐Cremades, Daniel, et al.
Publicado: (2017)

Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype
por: Beltrán-García, Jesús, et al.
Publicado: (2022)

An affordable method to obtain cultured endothelial cells from peripheral blood
por: Bueno-Betí, Carlos, et al.
Publicado: (2013)

Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation
por: Osca-Verdegal, Rebeca, et al.
Publicado: (2022)

Oxidative Stress and Epigenetics: miRNA Involvement in Rare Autoimmune Diseases
por: Ibáñez-Cabellos, José Santiago, et al.
Publicado: (2023)

miRNA as a New Regulatory Mechanism of Estrogen Vascular Action
por: Pérez-Cremades, Daniel, et al.
Publicado: (2018)

Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing
por: Pérez-Cremades, Daniel, et al.
Publicado: (2018)

Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis
por: Ibáñez-Cabellos, José Santiago, et al.
Publicado: (2019)

Small RNA-seq analysis of circulating miRNAs to identify phenotypic variability in Friedreich’s ataxia patients
por: Seco-Cervera, Marta, et al.
Publicado: (2018)

Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening
por: Ibáñez-Cabellos, José Santiago, et al.
Publicado: (2017)

Regulatory Network Analysis in Estradiol-Treated Human Endothelial Cells
por: Pérez-Cremades, Daniel, et al.
Publicado: (2021)

Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kB.
por: Sasaki, Makoto, et al.
Publicado: (2002)

Oxidative stress and antioxidant response in fibroblasts from Werner and Atypical Werner Syndromes
por: Seco-Cervera, Marta, et al.
Publicado: (2014)

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway
por: Zusso, Morena, et al.
Publicado: (2019)

Regulatory Mechanisms of Estrogen on Vascular Ageing
por: Novella, Susana, et al.
Publicado: (2019)

Catalpol Alleviates Depression by Inhibiting NLRP3 Inflammasome via TLR4/MAPK/NF-Kb Pathway
por: Liang, Xuemei, et al.
Publicado: (2023)

NF-kB and the CLL microenvironment
por: O’Donnell, Alice, et al.
Publicado: (2023)

Identification of circulating miRNAs differentially expressed in patients with Limb-girdle, Duchenne or facioscapulohumeral muscular dystrophies
por: García-Giménez, José Luis, et al.
Publicado: (2022)

TLR9 regulates NLRP3 inflammasome activation via the NF-kB signaling pathway in diabetic nephropathy
por: Shen, Jinfeng, et al.
Publicado: (2022)

STV‐Na attenuates lipopolysaccharide‐induced lung injury in mice via the TLR4/NF‐kB pathway
por: Xu, Yanhong, et al.
Publicado: (2023)

Modulation of cell proliferation, survival and gene expression by RAGE and TLR signaling in cells of the innate and adaptive immune response: role of p38 MAPK and NF-KB
por: de MEDEIROS, Marcell Costa, et al.
Publicado: (2014)

Vascular Aging in Women: is Estrogen the Fountain of Youth?
por: Novella, Susana, et al.
Publicado: (2012)

Salivary pellets induce a pro-inflammatory response involving the TLR4–NF-kB pathway in gingival fibroblasts
por: Müller, Heinz-Dieter H-D., et al.
Publicado: (2016)

Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway
por: Hu, Sunli, et al.
Publicado: (2020)

Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation
por: Han, Bing, et al.
Publicado: (2022)

Medicinal fungus Phellinus igniarius alleviates gout in vitro by modulating TLR4/NF-kB/NLRP3 signaling
por: Zhou, Xuebin, et al.
Publicado: (2022)

Salvia miltiorrhiza Extract Prevents the Occurrence of Early Atherosclerosis in Apoe (-/-) Mice via TLR4/ NF-kB Pathway
por: Wu, Ruoyu, et al.
Publicado: (2023)

miRNA-23b as a biomarker of culture-positive neonatal sepsis
por: Fatmi, Ahlam, et al.
Publicado: (2020)

Correction to: miRNA-23b as a biomarker of culture-positive neonatal sepsis
por: Fatmi, Ahlam, et al.
Publicado: (2020)

Induction of the pro-inflammatory NF-kB-sensitive miRNA-146a by human neurotrophic viruses
por: Hill, James M., et al.
Publicado: (2015)

Circulating miRNA Fingerprint and Endothelial Function in Myocardial Infarction: Comparison at Acute Event and One-Year Follow-Up
por: Mompeón, Ana, et al.
Publicado: (2022)

Immune-Enhancing Activity of Aqueous Extracts from Artemisia rupestris L. via MAPK and NF-kB Pathways of TLR4/TLR2 Downstream in Dendritic Cells
por: Yang, Yu, et al.
Publicado: (2020)

Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway
por: Dong, Xiaobo, et al.
Publicado: (2021)

Sorafenib inhibits LPS-induced inflammation by regulating Lyn-MAPK-NF-kB/AP-1 pathway and TLR4 expression
por: Li, Xiaolian, et al.
Publicado: (2022)

Activation of NF-kB Pathway by Virus Infection Requires Rb Expression
por: Garcia, Maria A., et al.
Publicado: (2009)

Reciprocal Regulation of NF-kB (Relish) and Subolesin in the Tick Vector, Ixodes scapularis
por: Naranjo, Victoria, et al.
Publicado: (2013)

Circulating miRNAs as diagnostic biomarkers for adolescent idiopathic scoliosis
por: García-Giménez, José Luis, et al.
Publicado: (2018)

TLR4-MyD88/Mal-NF-kB Axis Is Involved in Infection of HSV-2 in Human Cervical Epithelial Cells
por: Liu, Hongya, et al.
Publicado: (2013)

Peitu Shengjin Recipe Attenuates Airway Inflammation via the TLR4/NF-kB Signaling Pathway on Chronic Obstructive Pulmonary Disease
por: Hu, Xuzhen, et al.
Publicado: (2022)

Cellular Responses in Human Dental Pulp Stem Cells Treated with Three Endodontic Materials
por: Victoria-Escandell, Alejandro, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7ch9agildpe8qjh34n7f5a7qp5