Integrative dissection of gene regulatory elements at base resolution

Although vast numbers of putative gene regulatory elements have been cataloged, the sequence motifs and individual bases that underlie their functions remain largely unknown. Here, we combine epigenetic perturbations, base editing, and deep learning to dissect regulatory sequences within the exempla...

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Detalles Bibliográficos
Autores principales: Chen, Zeyu, Javed, Nauman, Moore, Molly, Wu, Jingyi, Sun, Gary, Vinyard, Michael, Collins, Alejandro, Pinello, Luca, Najm, Fadi J., Bernstein, Bradley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300548/
https://www.ncbi.nlm.nih.gov/pubmed/37388913
http://dx.doi.org/10.1016/j.xgen.2023.100318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300548/
https://www.ncbi.nlm.nih.gov/pubmed/37388913
http://dx.doi.org/10.1016/j.xgen.2023.100318

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