New Insights into the Opioid Analgesic Profile of cis-(−)-N-Normetazocine-derived Ligands

In this work, we report on the in vitro and in vivo pharmacological properties of LP1 analogs to complete the series of structural modifications aimed to generate compounds with improved analgesia. To do that, the phenyl ring in the N-substituent of our lead compound LP1 was replaced by an electron-...

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Detalles Bibliográficos
Autores principales: Costanzo, Giuliana, Turnaturi, Rita, Parenti, Carmela, Spoto, Salvatore, Piana, Silvia, Dichiara, Maria, Zagni, Chiara, Galambos, Anna Rita, Essmat, Nariman, Marrazzo, Agostino, Amata, Emanuele, Al-Khrasani, Mahmoud, Pasquinucci, Lorella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301092/
https://www.ncbi.nlm.nih.gov/pubmed/37375382
http://dx.doi.org/10.3390/molecules28124827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301092/
https://www.ncbi.nlm.nih.gov/pubmed/37375382
http://dx.doi.org/10.3390/molecules28124827

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