Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate

The dehydration of prednisolone sesquihydrate is studied and characterized by different physico-chemical analysis methods. The meticulous study of this dehydration led to the highlighting of a new solid form (form 3), metastable, never identified before. In a second step, the rehydration of anhydrou...

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Autores principales: Lemercier, Aurélien, Couvrat, Nicolas, Cartigny, Yohann, Sanselme, Morgane, Corvis, Yohann, Espeau, Philippe, Coquerel, Gérard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301155/
https://www.ncbi.nlm.nih.gov/pubmed/37376142
http://dx.doi.org/10.3390/pharmaceutics15061694
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author Lemercier, Aurélien
Couvrat, Nicolas
Cartigny, Yohann
Sanselme, Morgane
Corvis, Yohann
Espeau, Philippe
Coquerel, Gérard
author_facet Lemercier, Aurélien
Couvrat, Nicolas
Cartigny, Yohann
Sanselme, Morgane
Corvis, Yohann
Espeau, Philippe
Coquerel, Gérard
author_sort Lemercier, Aurélien
collection PubMed
description The dehydration of prednisolone sesquihydrate is studied and characterized by different physico-chemical analysis methods. The meticulous study of this dehydration led to the highlighting of a new solid form (form 3), metastable, never identified before. In a second step, the rehydration of anhydrous forms 1 and 2 of prednisolone is studied, in particular by Dynamic Vapor Sorption. It is then demonstrated that neither of the two forms is sensitive to humidity. By means of solid-gas equilibria, the sesquihydrate can only be obtainable from the isomorphic anhydrous form. Finally, a classification of the sesquihydrate is made, taking into account, in particular, the activation energy determined during dehydration.
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spelling pubmed-103011552023-06-29 Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate Lemercier, Aurélien Couvrat, Nicolas Cartigny, Yohann Sanselme, Morgane Corvis, Yohann Espeau, Philippe Coquerel, Gérard Pharmaceutics Article The dehydration of prednisolone sesquihydrate is studied and characterized by different physico-chemical analysis methods. The meticulous study of this dehydration led to the highlighting of a new solid form (form 3), metastable, never identified before. In a second step, the rehydration of anhydrous forms 1 and 2 of prednisolone is studied, in particular by Dynamic Vapor Sorption. It is then demonstrated that neither of the two forms is sensitive to humidity. By means of solid-gas equilibria, the sesquihydrate can only be obtainable from the isomorphic anhydrous form. Finally, a classification of the sesquihydrate is made, taking into account, in particular, the activation energy determined during dehydration. MDPI 2023-06-09 /pmc/articles/PMC10301155/ /pubmed/37376142 http://dx.doi.org/10.3390/pharmaceutics15061694 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lemercier, Aurélien
Couvrat, Nicolas
Cartigny, Yohann
Sanselme, Morgane
Corvis, Yohann
Espeau, Philippe
Coquerel, Gérard
Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate
title Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate
title_full Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate
title_fullStr Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate
title_full_unstemmed Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate
title_short Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate
title_sort evidence of a new crystalline phase of prednisolone obtained from the study of the hydration–dehydration mechanisms of the sesquihydrate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301155/
https://www.ncbi.nlm.nih.gov/pubmed/37376142
http://dx.doi.org/10.3390/pharmaceutics15061694
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