Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents

The design of colchicine site ligands on tubulin has proven to be a successful strategy to develop potent antiproliferative drugs against cancer cells. However, the structural requirements of the binding site endow the ligands with low aqueous solubility. In this work, the benzothiazole scaffold is...

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Detalles Bibliográficos
Autores principales: Gallego-Yerga, Laura, Ceña, Valentín, Peláez, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301603/
https://www.ncbi.nlm.nih.gov/pubmed/37376146
http://dx.doi.org/10.3390/pharmaceutics15061698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301603/
https://www.ncbi.nlm.nih.gov/pubmed/37376146
http://dx.doi.org/10.3390/pharmaceutics15061698

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