Uncovering the Kinetic Characteristics and Degradation Preference of PROTAC Systems with Advanced Theoretical Analyses

[Image: see text] Proteolysis-targeting chimeras (PROTACs), which can selectively induce the degradation of target proteins, represent an attractive technology in drug discovery. A large number of PROTACs have been reported, but due to the complicated structural and kinetic characteristics of the ta...

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Detalles Bibliográficos
Autores principales: Tang, Rongfan, Wang, Zhe, Xiang, Sutong, Wang, Lingling, Yu, Yang, Wang, Qinghua, Deng, Qirui, Hou, Tingjun, Sun, Huiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301679/
https://www.ncbi.nlm.nih.gov/pubmed/37388700
http://dx.doi.org/10.1021/jacsau.3c00195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301679/
https://www.ncbi.nlm.nih.gov/pubmed/37388700
http://dx.doi.org/10.1021/jacsau.3c00195

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