Cargando…

Uncovering the Kinetic Characteristics and Degradation Preference of PROTAC Systems with Advanced Theoretical Analyses

[Image: see text] Proteolysis-targeting chimeras (PROTACs), which can selectively induce the degradation of target proteins, represent an attractive technology in drug discovery. A large number of PROTACs have been reported, but due to the complicated structural and kinetic characteristics of the ta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Rongfan, Wang, Zhe, Xiang, Sutong, Wang, Lingling, Yu, Yang, Wang, Qinghua, Deng, Qirui, Hou, Tingjun, Sun, Huiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301679/ https://www.ncbi.nlm.nih.gov/pubmed/37388700 http://dx.doi.org/10.1021/jacsau.3c00195

Ejemplares similares

Deciphering the Shared and Specific Drug Resistance Mechanisms of Anaplastic Lymphoma Kinase via Binding Free Energy Computation
por: Yu, Yang, et al.
Publicado: (2023)

PROTAC-DB 2.0: an updated database of PROTACs
por: Weng, Gaoqi, et al.
Publicado: (2022)

PROTAC-DB: an online database of PROTACs
por: Weng, Gaoqi, et al.
Publicado: (2020)

Predicting the mutation effects of protein–ligand interactions via end-point binding free energy calculations: strategies and analyses
por: Yu, Yang, et al.
Publicado: (2022)

Degradation of proteins by PROTACs and other strategies
por: Wang, Yang, et al.
Publicado: (2020)

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope
por: Ma, Sinan, et al.
Publicado: (2022)

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate
por: Roy, Michael J., et al.
Publicado: (2019)

DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs
por: Li, Fenglei, et al.
Publicado: (2022)

Targeting Protein Kinases Degradation by PROTACs
por: Yu, Fei, et al.
Publicado: (2021)

Recent Advances of Degradation Technologies Based on PROTAC Mechanism
por: Xiao, Mingchao, et al.
Publicado: (2022)

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
por: Zhang, Qisi, et al.
Publicado: (2022)

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
por: Gasic, Ivana, et al.
Publicado: (2020)

RNA‐PROTACs: Degraders of RNA‐Binding Proteins
por: Ghidini, Alice, et al.
Publicado: (2020)

PROTAC targeted protein degraders: the past is prologue
por: Békés, Miklós, et al.
Publicado: (2022)

Mutant-selective degradation by BRAF-targeting PROTACs
por: Alabi, Shanique, et al.
Publicado: (2021)

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader
por: Tovell, Hannah, et al.
Publicado: (2019)

Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs
por: Qin, Qiaohua, et al.
Publicado: (2022)

Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)
por: Wang, Huifang, et al.
Publicado: (2023)

Degrading AR-Dependent Cancers: Expanding the Role of PROTACs
por: Michmerhuizen, Anna R., et al.
Publicado: (2020)

Light-Controllable PROTACs for Temporospatial Control of Protein Degradation
por: Liu, Jing, et al.
Publicado: (2021)

BacPROTACs mediate targeted protein degradation in bacteria
por: Morreale, Francesca E., et al.
Publicado: (2022)

A Temporal PROTAC Cocktail‐Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells
por: Liu, Fang, et al.
Publicado: (2022)

Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression
por: Chen, Si, et al.
Publicado: (2022)

Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells
por: Wang, Qiang, et al.
Publicado: (2023)

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
por: Zhang, Xiaoyu, et al.
Publicado: (2019)

Structural basis of PROTAC cooperative recognition for selective protein degradation
por: Gadd, Morgan S., et al.
Publicado: (2017)

Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs
por: Gabizon, Ronen, et al.
Publicado: (2020)

Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs
por: Naito, Mikihiko, et al.
Publicado: (2019)

PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
por: Qi, Si-Min, et al.
Publicado: (2021)

Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs
por: Alabi, Shanique B., et al.
Publicado: (2021)

Reversible Covalent PROTACs: Novel and Efficient Targeted Degradation Strategy
por: Yuan, Minghua, et al.
Publicado: (2021)

Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders
por: Hornberger, Keith R., et al.
Publicado: (2023)

PROTAC’ing oncoproteins: targeted protein degradation for cancer therapy
por: Kelm, Jeremy M., et al.
Publicado: (2023)

Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs
por: Negi, Arvind, et al.
Publicado: (2022)

Versatile Nano‐PROTAC‐Induced Epigenetic Reader Degradation for Efficient Lung Cancer Therapy
por: Zhang, Huan‐Tian, et al.
Publicado: (2022)

The PROTAC technology in drug development
por: Zou, Yutian, et al.
Publicado: (2019)

PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosis
por: Shi, Chengcheng, et al.
Publicado: (2019)

Developing potent PROTACs tools for selective degradation of HDAC6 protein
por: An, Zixuan, et al.
Publicado: (2019)

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity
por: Imaide, Satomi, et al.
Publicado: (2021)

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy
por: Li, Xin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ncuj1qmskvmjbvt89ib00pjqsf