Characterization of a Novel M4 PAM PET Radioligand [11C]PF06885190 in Nonhuman Primates (NHP)

Muscarinic acetylcholine receptors (mAChR), including M4, draw attention as therapeutic targets for several neurodegenerative diseases including Alzheimer’s disease (AD). PET imaging of M4 positive allosteric modulator (PAM) allows qualification of the distribution as well as the expression of this...

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Detalles Bibliográficos
Autores principales: Nag, Sangram, Arakawa, Ryosuke, Jia, Zhisheng, Lachapelle, Erik, Zhang, Lei, Maresca, Kevin, Chen, Laigao, Jahan, Mahabuba, Mccarthy, Timothy, Halldin, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301845/
https://www.ncbi.nlm.nih.gov/pubmed/37375167
http://dx.doi.org/10.3390/molecules28124612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301845/
https://www.ncbi.nlm.nih.gov/pubmed/37375167
http://dx.doi.org/10.3390/molecules28124612

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