Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting

Stiripentol (STP) is a new-generation antiepileptic only available for oral administration. However, it is extremely unstable in acidic environments and undergoes gastrointestinal slow and incomplete dissolution. Thus, STP intranasal (IN) administration might overcome the high oral doses required to...

Descripción completa

Detalles Bibliográficos
Autores principales: Meirinho, Sara, Rodrigues, Márcio, Santos, Adriana O., Falcão, Amílcar, Alves, Gilberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301887/
https://www.ncbi.nlm.nih.gov/pubmed/37376089
http://dx.doi.org/10.3390/pharmaceutics15061641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301887/
https://www.ncbi.nlm.nih.gov/pubmed/37376089
http://dx.doi.org/10.3390/pharmaceutics15061641

Ejemplares similares