Bicistronic CAR-T cells targeting CD123 and CLL1 for AML to reduce the risk of antigen escape

PURPOSE: Acute myeloid leukemia (AML) is a highly heterogeneous neoplastic disease with a poor prognosis that relapses even after its treatment with chimeric antigen receptor (CAR)-T cells targeting a single antigen. CD123 and CLL1 are expressed in most AML blasts and leukemia stem cells, and their...

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Detalles Bibliográficos
Autores principales: Xie, Danni, Jin, Xin, Sun, Rui, Zhang, Meng, Lu, Wenyi, Cao, Xinping, Guo, Ruiting, Zhang, Yi, Zhao, Mingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302120/
https://www.ncbi.nlm.nih.gov/pubmed/37224766
http://dx.doi.org/10.1016/j.tranon.2023.101695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302120/
https://www.ncbi.nlm.nih.gov/pubmed/37224766
http://dx.doi.org/10.1016/j.tranon.2023.101695

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