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Nutrient-dependent regulation of β-cell proinsulin content

Insulin is made from proinsulin, but the extent to which fasting/feeding controls the homeostatically regulated proinsulin pool in pancreatic β-cells remains largely unknown. Here, we first examined β-cell lines (INS1E and Min6, which proliferate slowly and are routinely fed fresh medium every 2–3 d...

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Detalles Bibliográficos
Autores principales:	Xu, Xiaoxi, Arunagiri, Anoop, Alam, Maroof, Haataja, Leena, Evans, Charles R., Zhao, Ivy, Castro-Gutierrez, Roberto, Russ, Holger A., Demangel, Caroline, Qi, Ling, Tsai, Billy, Liu, Ming, Arvan, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302188/ https://www.ncbi.nlm.nih.gov/pubmed/37209827 http://dx.doi.org/10.1016/j.jbc.2023.104836

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