Evolving Mutational Buildup in HIV-1 Protease Shifts Conformational Dynamics to Gain Drug Resistance

[Image: see text] Drug resistance in antiviral treatments is a serious public health problem. Viral proteins mutate very fast, giving them a way to escape drugs by lowering drug binding affinity but with compromised function. Human immunodeficiency virus type I (HIV-1) protease, a critical antiretro...

Descripción completa

Detalles Bibliográficos
Autores principales: Souffrant, Michael, Yao, Xin-Qiu, Hamelberg, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302472/
https://www.ncbi.nlm.nih.gov/pubmed/37285207
http://dx.doi.org/10.1021/acs.jcim.3c00535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302472/
https://www.ncbi.nlm.nih.gov/pubmed/37285207
http://dx.doi.org/10.1021/acs.jcim.3c00535

Ejemplares similares