Targeting transcriptional kinase of CDK7 halts proliferation of multiple myeloma cells by modulating the function of canonical NF-kB pathway and cell cycle regulatory proteins

Multiple myeloma (MM) is an incurable plasma cell neoplasm. Despite several effective frontline therapeutic regimens, including Bortezomib (BTZ), relapse is almost inevitable; therefore, better therapeutic modalities to improve the outcomes are needed. Cyclin-dependent kinases (CDKs) are an essentia...

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Detalles Bibliográficos
Autores principales: Dutta, Rudra Prasad, Kumar, Rohit, Tembhare, Prashant R., Bagal, Bhausaheb, Swain, Rajeeb Kumar, Hasan, Syed Khizer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302534/
https://www.ncbi.nlm.nih.gov/pubmed/37369156
http://dx.doi.org/10.1016/j.tranon.2023.101729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302534/
https://www.ncbi.nlm.nih.gov/pubmed/37369156
http://dx.doi.org/10.1016/j.tranon.2023.101729

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