Metabolomics Analysis as a Tool to Measure Cobalt Neurotoxicity: An In Vitro Validation

In this study, cobalt neurotoxicity was investigated in human astrocytoma and neuroblastoma (SH-SY5Y) cells using proliferation assays coupled with LC–MS-based metabolomics and transcriptomics techniques. Cells were treated with a range of cobalt concentrations between 0 and 200 µM. The 3-(4,5-dimet...

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Detalles Bibliográficos
Autores principales: Alanazi, Ibrahim M., R. Alzahrani, Abdullah, Zughaibi, Torki A., Al-Asmari, Ahmed I., Tabrez, Shams, Henderson, Catherine, Watson, David, Grant, Mary Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302852/
https://www.ncbi.nlm.nih.gov/pubmed/37367855
http://dx.doi.org/10.3390/metabo13060698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302852/
https://www.ncbi.nlm.nih.gov/pubmed/37367855
http://dx.doi.org/10.3390/metabo13060698

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