Cargando…

Metabolomics Analysis as a Tool to Measure Cobalt Neurotoxicity: An In Vitro Validation

In this study, cobalt neurotoxicity was investigated in human astrocytoma and neuroblastoma (SH-SY5Y) cells using proliferation assays coupled with LC–MS-based metabolomics and transcriptomics techniques. Cells were treated with a range of cobalt concentrations between 0 and 200 µM. The 3-(4,5-dimet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alanazi, Ibrahim M., R. Alzahrani, Abdullah, Zughaibi, Torki A., Al-Asmari, Ahmed I., Tabrez, Shams, Henderson, Catherine, Watson, David, Grant, Mary Helen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302852/ https://www.ncbi.nlm.nih.gov/pubmed/37367855 http://dx.doi.org/10.3390/metabo13060698

Ejemplares similares

Bioaccumulation of heavy metals and their toxicity assessment in Mystus species
por: Tabrez, Shams, et al.
Publicado: (2021)

Water quality index, Labeo rohita, and Eichhornia crassipes: Suitable bio-indicators of river water pollution
por: Tabrez, Shams, et al.
Publicado: (2022)

Analysis of some flavonoids for inhibitory mechanism against cancer target phosphatidylinositol 3-kinase (PI3K) using computational tool
por: Suhail, Mohd, et al.
Publicado: (2023)

Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach
por: Zughaibi, Torki A., et al.
Publicado: (2021)

Synergistic inhibition of glioblastoma multiforme through an in-silico analysis of luteolin and ferulic acid derived from Angelica sinensis and Cannabis sativa: Advancements in computational therapeutics
por: Suhail, Mohd, et al.
Publicado: (2023)

Targeting a transcription factor NF-κB by green tea catechins using in silico and in vitro studies in pancreatic cancer
por: Suhail, Mohd, et al.
Publicado: (2023)

Curcumin and Plumbagin Synergistically Target the PI3K/Akt/mTOR Pathway: A Prospective Role in Cancer Treatment
por: Ahmad, Iftikhar, et al.
Publicado: (2023)

A literature perspective on the pharmacological applications of yohimbine
por: Jabir, Nasimudeen R., et al.
Publicado: (2022)

Cobalt Neurotoxicity: Transcriptional Effect of Elevated Cobalt Blood Levels in the Rodent Brain
por: Gómez-Arnaiz, Sara, et al.
Publicado: (2022)

Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression
por: Tabrez, Shams, et al.
Publicado: (2022)

Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
por: Tabrez, Shams, et al.
Publicado: (2022)

Correction: Tabrez et al. Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression. Molecules 2022, 27, 5042
por: Tabrez, Shams, et al.
Publicado: (2022)

Post-Mortem Analysis of Heroin Biomarkers, Morphine and Codeine in Stomach Wall Tissue in Heroin-Related Deaths
por: Al-Asmari, Ahmed I., et al.
Publicado: (2022)

11-Nor-9-Carboxy Tetrahydrocannabinol Distribution in Fluid from the Chest Cavity in Cannabis-Related Post-Mortem Cases
por: Zughaibi, Torki A., et al.
Publicado: (2023)

Sugiol Suppresses the Proliferation of Human U87 Glioma Cells via Induction of Apoptosis and Cell Cycle Arrest
por: Alharthy, Saif A., et al.
Publicado: (2022)

Biogenic Synthesis of Cu-Mn Bimetallic Nanoparticles Using Pumpkin Seeds Extract and Their Characterization and Anticancer Efficacy
por: Alafaleq, Nouf Omar, et al.
Publicado: (2023)

Renal mitochondrial restoration by gymnemic acid in gentamicin-mediated experimental nephrotoxicity: evidence from serum, kidney and histopathological alterations
por: Gumbar, Shubhangi, et al.
Publicado: (2023)

Heroin-Related Fatalities in Jeddah, Saudi Arabia, between 2008 and 2018
por: Al-Asmari, Ahmed I., et al.
Publicado: (2023)

An Insight into Molecular Targets of Breast Cancer Brain Metastasis
por: Kaleem, Mohammed, et al.
Publicado: (2022)

Statistical analysis, source apportionment, and toxicity of particulate- and gaseous-phase PAHs in the urban atmosphere
por: Singh, Bhupendra Pratap, et al.
Publicado: (2023)

The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer
por: Muhammad, Naoshad, et al.
Publicado: (2022)

Concatenation of molecular docking and molecular simulation of BACE-1, γ-secretase targeted ligands: in pursuit of Alzheimer’s treatment
por: Jabir, Nasimudeen R., et al.
Publicado: (2021)

Where do T cell subsets stand in SARS-CoV-2 infection: an update
por: Tarique, Mohammad, et al.
Publicado: (2022)

Exploring the Natural Compounds in Flavonoids for Their Potential Inhibition of Cancer Therapeutic Target MEK1 Using Computational Methods
por: AlZahrani, Wejdan M., et al.
Publicado: (2022)

Forensic Analysis of Polymeric Carpet Fibers Using Direct Analysis in Real Time Coupled to an AccuTOF™ Mass Spectrometer
por: Zughaibi, Torki A., et al.
Publicado: (2021)

Insights into the Endocrine Disrupting Activity of Emerging Non-Phthalate Alternate Plasticizers against Thyroid Hormone Receptor: A Structural Perspective
por: Zughaibi, Torki A., et al.
Publicado: (2022)

Potential inflammatory targets in the integrative health care of patients with sickle cell disease
por: Khan, Shahida A, et al.
Publicado: (2023)

Validity and Reliability of an Assessment Tool for the Screening of Neurotoxic Effects in Agricultural Workers in Chile
por: Lucero, Boris, et al.
Publicado: (2019)

Cobalt-induced cardiomyopathy – do circulating cobalt levels matter?
por: Jenkinson, Mark R. J., et al.
Publicado: (2021)

Novel COVID-19: A Comprehensive Review of Transmission, Manifestation, and Pathogenesis
por: Hussain, Azhar, et al.
Publicado: (2020)

A Non-Instrumental Green Analytical Method Based on Surfactant-Assisted Dispersive Liquid–Liquid Microextraction–Thin-Layer Chromatography–Smartphone-Based Digital Image Colorimetry(SA-DLLME-TLC-SDIC) for Determining Favipiravir in Biological Samples
por: Jain, Bharti, et al.
Publicado: (2023)

Assessing the performance of statistical validation tools for megavariate metabolomics data
por: Rubingh, Carina M., et al.
Publicado: (2006)

Cobalt Administration Causes Reduced Contractility with Parallel Increases in TRPC6 and TRPM7 Transporter Protein Expression in Adult Rat Hearts
por: Laovitthayanggoon, Sarunya, et al.
Publicado: (2018)

Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels/Metabolism
por: Alasmari, Fawaz, et al.
Publicado: (2018)

Involvement of Phytochemical-Encapsulated Nanoparticles’ Interaction with Cellular Signalling in the Amelioration of Benign and Malignant Brain Tumours
por: Mehan, Sidharth, et al.
Publicado: (2022)

Vitamin C: A Preventative, Therapeutic Agent Against Helicobacter pylori
por: Hussain, Azhar, et al.
Publicado: (2018)

Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation
por: Koch, Katharina, et al.
Publicado: (2022)

Methylmercury exposure and developmental neurotoxicity
por: Myers, Gary J, et al.
Publicado: (2015)

Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice
por: Zhang, Kai-Kai, et al.
Publicado: (2022)

Elucidation of the Molecular Mechanisms Underlying Sorafenib-Induced Hepatotoxicity
por: AlAsmari, Abdullah F., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_co7rb0drvcgme8b9ao8ua9pttm