Cargando…

Clorgyline Analogs Synergize with Azoles against Drug Efflux in Candida auris

Concern about the global emergence of multidrug-resistant fungal pathogens led us to explore the use of combination therapy to combat azole resistance in Candida auris. Clorgyline had previously been shown to be a multi-target inhibitor of Cdr1 and Mdr1 efflux pumps of Candida albicans and Candida g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toepfer, Stephanie, Lackner, Michaela, Keniya, Mikhail V., Zenz, Lisa-Maria, Friemert, Marianne, Bracher, Franz, Monk, Brian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303049/ https://www.ncbi.nlm.nih.gov/pubmed/37367600 http://dx.doi.org/10.3390/jof9060663

Ejemplares similares

Functional Expression of Recombinant Candida auris Proteins in Saccharomyces cerevisiae Enables Azole Susceptibility Evaluation and Drug Discovery
por: Toepfer, Stephanie, et al.
Publicado: (2023)

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
por: Iyer, Kali R., et al.
Publicado: (2020)

On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds
por: Casadevall, Arturo, et al.
Publicado: (2019)

Virulence Traits and Azole Resistance in Korean Candida auris Isolates
por: Byun, Seung A., et al.
Publicado: (2023)

Exploring synergy between azole antifungal drugs and statins for Candida auris
por: Halliday, Catriona, et al.
Publicado: (2023)

Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance
por: Kim, Sang Hu, et al.
Publicado: (2019)

Multilocus sequence typing of azole-resistant Candida auris strains, South Africa
por: Magobo, Rindidzani, et al.
Publicado: (2020)

Directed Evolution Detects Supernumerary Centric Chromosomes Conferring Resistance to Azoles in Candida auris
por: Narayanan, Aswathy, et al.
Publicado: (2022)

Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate
por: Graham, Danyon O., et al.
Publicado: (2021)

P021 Comparative transcriptomic analysis of environmental Candida auris showing variable azole susceptibility
por: Jain, Kusum, et al.
Publicado: (2022)

Erratum for Kim et al., “Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance”
por: Kim, Sang Hu, et al.
Publicado: (2019)

Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus
por: Arikan-Akdagli, Sevtap, et al.
Publicado: (2018)

Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility
por: Healey, Kelley R., et al.
Publicado: (2018)

P005 Competitive fitness and trade-offs associated with azole resistance in Candida auris clinical isolates
por: Das, Sourav, et al.
Publicado: (2022)

Aprepitant, an antiemetic agent, interferes with metal ion homeostasis of Candida auris and displays potent synergistic interactions with azole drugs
por: Eldesouky, Hassan E., et al.
Publicado: (2020)

Is Candida auris sexual?
por: Ross, Zoe K., et al.
Publicado: (2020)

Candida auris is Coming
por: Hegde, Ashit
Publicado: (2022)

Antifungal Activity and Synergism with Azoles of Polish Propolis
por: Gucwa, Katarzyna, et al.
Publicado: (2018)

The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
por: Wang, Keliang, et al.
Publicado: (2020)

Sterol 14α-Demethylase Ligand-Binding Pocket-Mediated Acquired and Intrinsic Azole Resistance in Fungal Pathogens
por: Rosam, Katharina, et al.
Publicado: (2020)

NO Candida auris: Nitric Oxide in Nanotherapeutics to Combat Emerging Fungal Pathogen Candida auris
por: Cleare, Levi G., et al.
Publicado: (2020)

Azole resistance in Candida spp. isolated from Catú Lake, Ceará, Brazil: an efflux-pump-mediated mechanism
por: Brilhante, Raimunda S.N., et al.
Publicado: (2016)

Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinical Candida albicans and non-albicans isolates
por: El-Ganiny, Amira M., et al.
Publicado: (2022)

Azole potentiation in Candida species
por: Stenkiewicz-Witeska, Jan S., et al.
Publicado: (2023)

Candida auris in the Age of Resistance
por: Oh, Michael, et al.
Publicado: (2020)

Candida auris in Dog Ears
por: Yadav, Anamika, et al.
Publicado: (2023)

Immunopathogenesis of Emerging Candida auris and Candida haemulonii Strains
por: Pharkjaksu, Sujiraphong, et al.
Publicado: (2021)

Characterisation of Candida parapsilosis CYP51 as a Drug Target Using Saccharomyces cerevisiae as Host
por: Ruma, Yasmeen N., et al.
Publicado: (2022)

Verapamil inhibits efflux pumps in Candida albicans, exhibits synergism with fluconazole, and increases survival of Galleria mellonella
por: Vega-Chacón, Yuliana, et al.
Publicado: (2021)

Candida auris Candidemia in Kuwait, 2014
por: Emara, Maha, et al.
Publicado: (2015)

Identification of Drug Resistant Candida auris
por: Kordalewska, Milena, et al.
Publicado: (2019)

Candida auris: An emerging pathogen “incognito”?
por: Nett, Jeniel E.
Publicado: (2019)

Candida auris Bloodstream Infections in Russia
por: Barantsevich, Natalia E., et al.
Publicado: (2020)

Candida auris—“Ten Years After”
por: Meis, Jacques F., et al.
Publicado: (2019)

Incursions of Candida auris into Australia, 2018
por: Lane, Courtney R., et al.
Publicado: (2020)

An Overview on Candida auris in Healthcare Settings
por: Cristina, Maria Luisa, et al.
Publicado: (2023)

Candida auris in skilled nursing facilities
por: Yune, Philip S., et al.
Publicado: (2023)

2474. Emergence of Candida auris in Michigan
por: McNamara, Sara E, et al.
Publicado: (2023)

Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus
por: Kim, Minchul, et al.
Publicado: (2017)

Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance
por: Keniya, Mikhail V., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_tccnq0f9l5no77btus3g49m4lc