Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling Pathway

The epigenetic silencing of tumor suppressor genes (TSGs) is critical in the development of chronic myeloid leukemia (CML). SHP-1 functions as a TSG and negatively regulates JAK/STAT signaling. Enhancement of SHP-1 expression by demethylation provides molecular targets for the treatment of various c...

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Detalles Bibliográficos
Autores principales: Al-Rawashde, Futoon Abedrabbu, Al-Sanabra, Ola M., Alqaraleh, Moath, Jaradat, Ahmad Q., Al-Wajeeh, Abdullah Saleh, Johan, Muhammad Farid, Wan Taib, Wan Rohani, Ismail, Imilia, Al-Jamal, Hamid Ali Nagi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303097/
https://www.ncbi.nlm.nih.gov/pubmed/37375831
http://dx.doi.org/10.3390/ph16060884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303097/
https://www.ncbi.nlm.nih.gov/pubmed/37375831
http://dx.doi.org/10.3390/ph16060884

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