Cargando…

Conjugation of Triterpenic Acids of Ursane and Oleanane Types with Mitochondria-Targeting Cation F16 Synergistically Enhanced Their Cytotoxicity against Tumor Cells

The present work shows the cytotoxic effects of novel conjugates of ursolic, oleanolic, maslinic, and corosolic acids with the penetrating cation F16 on cancer cells (lung adenocarcinoma A549 and H1299, breast cancer cell lines MCF-7 and BT474) and non-tumor human fibroblasts. It has been establishe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dubinin, Mikhail V., Nedopekina, Darya A., Ilzorkina, Anna I., Semenova, Alena A., Sharapov, Vyacheslav A., Davletshin, Eldar V., Mikina, Natalia V., Belsky, Yuri P., Spivak, Anna Yu., Akatov, Vladimir S., Belosludtseva, Natalia V., Liu, Jiankang, Belosludtsev, Konstantin N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303159/ https://www.ncbi.nlm.nih.gov/pubmed/37367767 http://dx.doi.org/10.3390/membranes13060563

Ejemplares similares

Biotransformation of Oleanane and Ursane Triterpenic Acids
por: Luchnikova, Natalia A., et al.
Publicado: (2020)

Comparative Study of Cytotoxic and Membranotropic Properties of Betulinic Acid-F16 Conjugate on Breast Adenocarcinoma Cells (MCF-7) and Primary Human Fibroblasts
por: Belosludtsev, Konstantin N., et al.
Publicado: (2022)

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives
por: e Silva, Maria de L., et al.
Publicado: (2012)

Effect of F16-Betulin Conjugate on Mitochondrial Membranes and Its Role in Cell Death Initiation
por: Dubinin, Mikhail V., et al.
Publicado: (2021)

Conjugation of Natural Triterpenic Acids with Delocalized Lipophilic Cations: Selective Targeting Cancer Cell Mitochondria
por: Spivak, Anna Yu., et al.
Publicado: (2021)

Effect of Modified Levopimaric Acid Diene Adducts on Mitochondrial and Liposome Membranes
por: Dubinin, Mikhail V., et al.
Publicado: (2022)

Cytotoxic activities of naturally occurring oleanane-, ursane-, and lupane-type triterpenes on HepG2 and AGS cells
por: Yang, Heejung, et al.
Publicado: (2017)

Genome-Wide Identification of OSC Gene Family and Potential Function in the Synthesis of Ursane- and Oleanane-Type Triterpene in Momordica charantia
por: Han, Yutong, et al.
Publicado: (2021)

Identification of novel compounds, oleanane- and ursane-type triterpene glycosides, from Trevesia palmata: their biocontrol activity against phytopathogenic fungi
por: Kim, Bora, et al.
Publicado: (2018)

Pharmacological and Genetic Suppression of VDAC1 Alleviates the Development of Mitochondrial Dysfunction in Endothelial and Fibroblast Cell Cultures upon Hyperglycemic Conditions
por: Belosludtsev, Konstantin N., et al.
Publicado: (2023)

Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
por: Belosludtsev, Konstantin N., et al.
Publicado: (2020)

S-15176 Difumarate Salt Can Impair Mitochondrial Function through Inhibition of the Respiratory Complex III and Permeabilization of the Inner Mitochondrial Membrane
por: Belosludtseva, Natalia V., et al.
Publicado: (2022)

New biofunctional effects of oleanane-type triterpene saponins
por: Matsuda, Hisashi, et al.
Publicado: (2023)

Three New Ring-A Modified Ursane Triterpenes from Davidia involucrata
por: Tan, Qing-Wei, et al.
Publicado: (2014)

Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from Globimetula braunii Leaf
por: Oriola, Ayodeji Oluwabunmi, et al.
Publicado: (2021)

Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives
por: Spivak, Anna, et al.
Publicado: (2018)

Biological Activity of Oleanane Triterpene Derivatives Obtained by Chemical Derivatization
por: Cheng, Shi-Yie, et al.
Publicado: (2013)

Publisher Correction: New biofunctional effects of oleanane-type triterpene saponins
por: Matsuda, Hisashi, et al.
Publicado: (2023)

Molecular and Pharmacokinetic Aspects of the Acetylcholinesterase-Inhibitory Potential of the Oleanane-Type Triterpenes and Their Glycosides
por: Stępnik, Katarzyna, et al.
Publicado: (2023)

Alisporivir Normalizes Mitochondrial Function of Primary Mouse Lung Endothelial Cells Under Conditions of Hyperglycemia
por: Starinets, Vlada S., et al.
Publicado: (2022)

3-Pyridinylidene Derivatives of Chemically Modified Lupane and Ursane Triterpenes as Promising Anticancer Agents by Targeting Apoptosis
por: Kazakova, Oxana, et al.
Publicado: (2021)

Effect of Chronic Treatment with Uridine on Cardiac Mitochondrial Dysfunction in the C57BL/6 Mouse Model of High-Fat Diet–Streptozotocin-Induced Diabetes
por: Belosludtseva, Natalia V., et al.
Publicado: (2022)

Transport of Ca(2+) and Ca(2+)-Dependent Permeability Transition in Rat Liver Mitochondria under the Streptozotocin-Induced Type I Diabetes
por: Belosludtsev, Konstantin N., et al.
Publicado: (2019)

The Effect of Deflazacort Treatment on the Functioning of Skeletal Muscle Mitochondria in Duchenne Muscular Dystrophy
por: Dubinin, Mikhail V., et al.
Publicado: (2020)

Effect of the MPT Pore Inhibitor Alisporivir on the Development of Mitochondrial Dysfunction in the Heart Tissue of Diabetic Mice
por: Belosludtseva, Natalia V., et al.
Publicado: (2021)

Effect of the Non-Immunosuppressive MPT Pore Inhibitor Alisporivir on the Functioning of Heart Mitochondria in Dystrophin-Deficient mdx Mice
por: Dubinin, Mikhail V., et al.
Publicado: (2021)

The Effect of S-15176 Difumarate Salt on Ultrastructure and Functions of Liver Mitochondria of C57BL/6 Mice with Streptozotocin/High-Fat Diet-Induced Type 2 Diabetes
por: Belosludtseva, Natalia V., et al.
Publicado: (2020)

Alisporivir Improves Mitochondrial Function in Skeletal Muscle of mdx Mice but Suppresses Mitochondrial Dynamics and Biogenesis
por: Dubinin, Mikhail V., et al.
Publicado: (2021)

Alisporivir Treatment Alleviates Mitochondrial Dysfunction in the Skeletal Muscles of C57BL/6NCrl Mice with High-Fat Diet/Streptozotocin-Induced Diabetes Mellitus
por: Belosludtsev, Konstantin N., et al.
Publicado: (2021)

Alterations in Mitochondrial Morphology and Quality Control in Primary Mouse Lung Microvascular Endothelial Cells and Human Dermal Fibroblasts under Hyperglycemic Conditions
por: Belosludtseva, Natalia V., et al.
Publicado: (2023)

Transport of Ca(2+) and Ca(2+)-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia
por: Belosludtsev, Konstantin N., et al.
Publicado: (2020)

Oleanane-Type Triterpene Conjugates with 1H-1,2,3-Triazole Possessing of Fungicidal Activity
por: Chen, Zili, et al.
Publicado: (2022)

Effect of Fusidic Acid and Some Nitrogen-Containing Derivatives on Liposomal and Mitochondrial Membranes
por: Dubinin, Mikhail V., et al.
Publicado: (2023)

Isomadecassoside, a New Ursane-Type Triterpene Glycoside from Centella asiatica Leaves, Reduces Nitrite Levels in LPS-Stimulated Macrophages
por: Chianese, Giuseppina, et al.
Publicado: (2021)

Abubidentin A, New Oleanane-type Triterpene Ester from Abutilon bidentatum and its antioxidant, cholinesterase and antimicrobial activities
por: A. Al-Hamoud, Gadah, et al.
Publicado: (2022)

Effect of Dapagliflozin on the Functioning of Rat Liver Mitochondria In Vitro
por: Belosludtseva, N. V., et al.
Publicado: (2021)

The Effect of Uridine on the State of Skeletal Muscles and the Functioning of Mitochondria in Duchenne Dystrophy
por: Dubinin, Mikhail V., et al.
Publicado: (2022)

New biofunctional effects of the flower buds of Camellia sinensis and its bioactive acylated oleanane-type triterpene oligoglycosides
por: Matsuda, Hisashi, et al.
Publicado: (2016)

Two New Oleanane-Type Triterpenes Isolated from Japanese Post-Fermented Tea Produced by Anaerobic Microbial Fermentation
por: Huang, Yong-Lin, et al.
Publicado: (2013)

Novel Oleanane-Type Triterpene Glycosides from the Saponaria officinalis L. Seeds and Apoptosis-Inducing Activity via Mitochondria
por: Takahashi, Naoki, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rek37vr9j1hk18qn5lr54uuknj