Synthesis and Receptor Binding Studies of α5 GABA(A)R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders

GABA mediates inhibitory actions through various GABA(A) receptor subtypes, including 19 subunits in human GABAAR. Dysregulation of GABAergic neurotransmission is associated with several psychiatric disorders, including depression, anxiety, and schizophrenia. Selective targeting of α2/3 GABAARs can...

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Detalles Bibliográficos
Autores principales: Sharmin, Dishary, Mian, Md Yeunus, Marcotte, Michael, Prevot, Thomas D., Sibille, Etienne, Witkin, Jeffrey M., Cook, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303271/
https://www.ncbi.nlm.nih.gov/pubmed/37375326
http://dx.doi.org/10.3390/molecules28124771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303271/
https://www.ncbi.nlm.nih.gov/pubmed/37375326
http://dx.doi.org/10.3390/molecules28124771

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