Protein Corona Attenuates the Targeting of Antitumor Sialyl Lewis X-Decorated Liposomes to Vascular Endothelial Cells under Flow Conditions

Previously, we showed in the human umbilical vein endothelial cells (HUVECs) model that a liposome formulation of melphalan lipophilic prodrug (MlphDG) decorated with selectin ligand tetrasaccharide Sialyl Lewis X (SiaLe(X)) undergoes specific uptake by activated cells and in an in vivo tumor model...

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Detalles Bibliográficos
Autores principales: Onishchenko, Natalia R., Moskovtsev, Alexey A., Kobanenko, Maria K., Tretiakova, Daria S., Alekseeva, Anna S., Kolesov, Dmitry V., Mikryukova, Anna A., Boldyrev, Ivan A., Kapkaeva, Marina R., Shcheglovitova, Olga N., Bovin, Nicolai V., Kubatiev, Aslan A., Tikhonova, Olga V., Vodovozova, Elena L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303272/
https://www.ncbi.nlm.nih.gov/pubmed/37376203
http://dx.doi.org/10.3390/pharmaceutics15061754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303272/
https://www.ncbi.nlm.nih.gov/pubmed/37376203
http://dx.doi.org/10.3390/pharmaceutics15061754

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