Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect models

BACKGROUND: Evaluation of parasite clearance patterns in experimental human infection trials helps increase understanding of drug action. In a previously reported phase Ib trial of a new investigational anti-malarial drug M5717, parasite clearance showed a biphasic linear pattern: slow removal phase...

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Detalles Bibliográficos
Autores principales: Yin, Xiaoyan, Li, Ying, Bagchus, Wilhelmina, Yalkinoglu, Özkan, Bezuidenhout, Deon, Tappert, Aliona, McCarthy, James, Marquart, Louise, Oeuvray, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303793/
https://www.ncbi.nlm.nih.gov/pubmed/37381013
http://dx.doi.org/10.1186/s12936-023-04627-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303793/
https://www.ncbi.nlm.nih.gov/pubmed/37381013
http://dx.doi.org/10.1186/s12936-023-04627-x

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