Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones

The stereochemical properties of N-acyl-5H-dibenzo[b,d]azepin-7(6H)-ones (2a–c), which inhibit potassium channels in T cells, were examined by freezing their conformational change due to 4-methyl substitution. N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones exist as pairs of enantiomers [(a(1)R, a(2)R), (a(...

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Detalles Bibliográficos
Autores principales: Chiba, Arisa, Tanaka, Ryoko, Hotta, Mayuno, Nakamura, Kayo, Makino, Kosho, Tabata, Hidetsugu, Oshitari, Tetsuta, Natsugari, Hideaki, Takahashi, Hideyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303827/
https://www.ncbi.nlm.nih.gov/pubmed/37375290
http://dx.doi.org/10.3390/molecules28124734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303827/
https://www.ncbi.nlm.nih.gov/pubmed/37375290
http://dx.doi.org/10.3390/molecules28124734

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