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Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure—Activity Relationship Studies
In this work, the design and synthesis of a new chalcone-trimethoxycinnamide hybrid (7) based on the combination of subunits of two promising antiproliferative compounds (CM-M345 (1) and BP-M345 (2)), previously obtained by our research group, are reported. In order to expand the structure–activity...
Autores principales: | Moreira, Joana, Silva, Patrícia M. A., Barros, Matilde, Saraiva, Lucília, Pinto, Madalena, Bousbaa, Hassan, Cidade, Honorina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303900/ https://www.ncbi.nlm.nih.gov/pubmed/37375826 http://dx.doi.org/10.3390/ph16060879 |
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