The Oncolytic herpes simplex virus type-1 (HSV-1) vaccine strain VC2 causes intratumor infiltration of functionally active T cells and inhibition of tumor metastasis and pro-tumor genes VEGF and PDL1 expression in the 4T1/Balb/c mouse model of stage four breast cancer

Introduction: Oncolytic viruses (OVs) provide new modalities for cancer therapy either alone or in combination with synergistic immunotherapies and/or chemotherapeutics. Engineered Herpes Simplex Virus Type-1 (HSV-1) has shown strong promise for the treatment of various cancers in experimental anima...

Descripción completa

Detalles Bibliográficos
Autores principales: Nabi, Rafiq, Musarrat, Farhana, Menk P. Lima, Jose Cesar, Langohr, Ingeborg M., Chouljenko, Vladimir N., Kousoulas, Konstantin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303929/
https://www.ncbi.nlm.nih.gov/pubmed/37388243
http://dx.doi.org/10.3389/fmolb.2023.1199068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303929/
https://www.ncbi.nlm.nih.gov/pubmed/37388243
http://dx.doi.org/10.3389/fmolb.2023.1199068

Ejemplares similares