Therapeutic activity of lipoxin A(4) in TiO(2)-induced arthritis in mice: NF-κB and Nrf2 in synovial fluid leukocytes and neuronal TRPV1 mechanisms

BACKGROUND: Lipoxin A4 (LXA(4)) has anti-inflammatory and pro-resolutive roles in inflammation. We evaluated the effects and mechanisms of action of LXA4 in titanium dioxide (TiO(2)) arthritis, a model of prosthesis-induced joint inflammation and pain. METHODS: Mice were stimulated with TiO(2) (3mg)...

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Detalles Bibliográficos
Autores principales: Saraiva-Santos, Telma, Zaninelli, Tiago H., Manchope, Marília F., Andrade, Ketlem C., Ferraz, Camila R., Bertozzi, Mariana M., Artero, Nayara A., Franciosi, Anelise, Badaro-Garcia, Stephanie, Staurengo-Ferrari, Larissa, Borghi, Sergio M., Ceravolo, Graziela S., Andrello, Avacir Casanova, Zanoveli, Janaína Menezes, Rogers, Michael S., Casagrande, Rubia, Pinho-Ribeiro, Felipe A., Verri, Waldiceu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304281/
https://www.ncbi.nlm.nih.gov/pubmed/37388729
http://dx.doi.org/10.3389/fimmu.2023.949407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304281/
https://www.ncbi.nlm.nih.gov/pubmed/37388729
http://dx.doi.org/10.3389/fimmu.2023.949407

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