Increased Bone Marrow Uptake and Accumulation of Very-Late Antigen-4 Targeted Lipid Nanoparticles

Lipid nanoparticles (LNPs) have evolved rapidly as promising delivery systems for oligonucleotides, including siRNAs. However, current clinical LNP formulations show high liver accumulation after systemic administration, which is unfavorable for the treatment of extrahepatic diseases, such as hemato...

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Detalles Bibliográficos
Autores principales: Swart, Laura E., Fens, Marcel H. A. M., van Oort, Anita, Waranecki, Piotr, Mata Casimiro, L. Daniel, Tuk, David, Hendriksen, Martijn, van den Brink, Luca, Schweighart, Elizabeth, Seinen, Cor, Nelson, Ryan, Krippner-Heidenreich, Anja, O’Toole, Tom, Schiffelers, Raymond M., Kooijmans, Sander, Heidenreich, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304323/
https://www.ncbi.nlm.nih.gov/pubmed/37376052
http://dx.doi.org/10.3390/pharmaceutics15061603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304323/
https://www.ncbi.nlm.nih.gov/pubmed/37376052
http://dx.doi.org/10.3390/pharmaceutics15061603

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