Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes

Gain-of-function mutations in the LRRK2 gene cause Parkinson’s disease (PD), increasing phosphorylation of RAB GTPases through hyperactive kinase activity. We find that LRRK2-hyperphosphorylated RABs disrupt the axonal transport of autophagosomes by perturbing the coordinated regulation of cytoplasm...

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Detalles Bibliográficos
Autores principales: Dou, Dan, Smith, Erin M., Evans, Chantell S., Boecker, C. Alexander, Holzbaur, Erika L.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304398/
https://www.ncbi.nlm.nih.gov/pubmed/37133994
http://dx.doi.org/10.1016/j.celrep.2023.112448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304398/
https://www.ncbi.nlm.nih.gov/pubmed/37133994
http://dx.doi.org/10.1016/j.celrep.2023.112448

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