PKM2 dictates the poised chromatin state of PFKFB3 promoter to enhance breast cancer progression

The hypoxic milieu is a critical modulator of aerobic glycolysis, yet the regulatory mechanisms between the key glycolytic enzymes in hypoxic cancer cells are largely unchartered. In particular, the M2 isoform of pyruvate kinase (PKM2), the rate-limiting enzyme of glycolysis, is known to confer adap...

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Detalles Bibliográficos
Autores principales: Pandkar, Madhura R, Raveendran, Adarsh, Biswas, Kajal, Mutnuru, Srinivas Abhishek, Mishra, Jharna, Samaiya, Atul, Malys, Tyler, Mitrophanov, Alexander Y, Sharan, Shyam K, Shukla, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304768/
https://www.ncbi.nlm.nih.gov/pubmed/37388539
http://dx.doi.org/10.1093/narcan/zcad032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304768/
https://www.ncbi.nlm.nih.gov/pubmed/37388539
http://dx.doi.org/10.1093/narcan/zcad032

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