Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists. These compounds were designed to lessen the lipophilicity obse...

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Detalles Bibliográficos
Autores principales: Lutz, Joshua A., Sulima, Agnieszka, Gutman, Eugene S., Bow, Eric W., Luo, Dan, Kaska, Sophia, Prisinzano, Thomas E., Paronis, Carol A., Bergman, Jack, Imler, Gregory H., Kerr, Andrew T., Jacobson, Arthur E., Rice, Kenner C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304876/
https://www.ncbi.nlm.nih.gov/pubmed/37375350
http://dx.doi.org/10.3390/molecules28124795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304876/
https://www.ncbi.nlm.nih.gov/pubmed/37375350
http://dx.doi.org/10.3390/molecules28124795

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