A unique melanocortin-4-receptor signaling profile for obesity-associated constitutively active variants

The melanocortin-4 receptor (MC4R) plays a critical role in regulating energy homeostasis. Studies on obesogenic human MC4R (hMC4R) variants have not yet revealed how hMC4R maintains body weight. Here, we identified a signaling profile for obesogenic constitutively active H76R and L250Q hMC4R varian...

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Detalles Bibliográficos
Autores principales: Botha, Rikus, Kumar, Shree S, Grimsey, Natasha L, Mountjoy, Kathleen G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304906/
https://www.ncbi.nlm.nih.gov/pubmed/37040537
http://dx.doi.org/10.1530/JME-23-0008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304906/
https://www.ncbi.nlm.nih.gov/pubmed/37040537
http://dx.doi.org/10.1530/JME-23-0008

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