Cargando…

A unique melanocortin-4-receptor signaling profile for obesity-associated constitutively active variants

The melanocortin-4 receptor (MC4R) plays a critical role in regulating energy homeostasis. Studies on obesogenic human MC4R (hMC4R) variants have not yet revealed how hMC4R maintains body weight. Here, we identified a signaling profile for obesogenic constitutively active H76R and L250Q hMC4R varian...

Descripción completa

Detalles Bibliográficos
Autores principales:	Botha, Rikus, Kumar, Shree S, Grimsey, Natasha L, Mountjoy, Kathleen G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304906/ https://www.ncbi.nlm.nih.gov/pubmed/37040537 http://dx.doi.org/10.1530/JME-23-0008

Ejemplares similares

SAT-598 Shared Signaling Profile Between Human MRAPα-Induced Human MC4R Constitutive Activity and Obesity-Associated Human MC4R Constitutive Activity
por: Botha, Rikus, et al.
Publicado: (2020)

hMRAPα, but Not hMRAP2, Enhances hMC4R Constitutive Activity in HEK293 Cells and This Is Not Dependent on hMRAPα Induced Changes in hMC4R Complex N-linked Glycosylation
por: Kay, Emma I., et al.
Publicado: (2015)

Distinct Calcium Signaling for Wildtype, Loss-of-Function and Gain-of-Function Human MC4R Variants
por: Kumar, Shree S, et al.
Publicado: (2021)

Engineering the Melanocortin-4 Receptor to Control Constitutive and Ligand-Mediated G(s) Signaling In Vivo
por: Srinivasan, Supriya, et al.
Publicado: (2007)

Gene Expression Regulation by Agonist-Independent Constitutive Signaling of Melanocortin-1 Receptor
por: Seong, Ikjoo, et al.
Publicado: (2014)

SAT027 Novel Obesity-Associated Melanocortin 4 Receptor Variants Modulate Signaling Differently
por: Rodriguez Rondon, Alejandra V, et al.
Publicado: (2023)

Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders
por: Lucas, Nicolas, et al.
Publicado: (2019)

Melanocortins, Melanocortin Receptors and Multiple Sclerosis
por: Lisak, Robert P., et al.
Publicado: (2017)

Melanocortin receptor accessory proteins in adrenal disease and obesity
por: Jackson, David S., et al.
Publicado: (2015)

Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector
por: Siu, Jason J., et al.
Publicado: (2017)

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling
por: Wang, Xiaozhu, et al.
Publicado: (2022)

Structural Complexity and Plasticity of Signaling Regulation at the Melanocortin-4 Receptor
por: Kleinau, Gunnar, et al.
Publicado: (2020)

The Multifaceted Melanocortin Receptors
por: Laiho, Linda, et al.
Publicado: (2022)

Functional variants of the melanocortin-4 receptor associated with the Odontoceti and Mysticeti suborders of cetaceans
por: Zhao, Liyuan, et al.
Publicado: (2017)

Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice
por: Sandrock, Mara, et al.
Publicado: (2009)

Melanocortin‐4 receptor complexity in energy homeostasis,obesity and drug development strategies
por: Fatima, Munazza Tamkeen, et al.
Publicado: (2022)

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors
por: Michael, Natalie J., et al.
Publicado: (2020)

Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor
por: Soletto, Lucia, et al.
Publicado: (2018)

Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2
por: Ji, Ren-Lei, et al.
Publicado: (2022)

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2
por: Ji, Ren-Lei, et al.
Publicado: (2022)

Defect in MAPK Signaling As a Cause for Monogenic Obesity Caused By Inactivating Mutations in the Melanocortin-4 Receptor Gene
por: He, Shan, et al.
Publicado: (2014)

Observations on the Evolution of the Melanocortin Receptor Gene Family: Distinctive Features of the Melanocortin-2 Receptor
por: Dores, Robert M.
Publicado: (2013)

The central melanocortin system and human obesity
por: Yang, Yongjie, et al.
Publicado: (2020)

Data for amino acid alignment of Japanese stingray melanocortin receptors with other gnathostome melanocortin receptor sequences, and the ligand selectivity of Japanese stingray melanocortin receptors
por: Takahashi, Akiyoshi, et al.
Publicado: (2016)

Melanocortin Receptor 4 (MC4R) Signaling System in Nile Tilapia
por: Liu, Tianqiang, et al.
Publicado: (2020)

Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity
por: Šket, Robert, et al.
Publicado: (2022)

Physical Activity and Sedentary Behaviors Modify the Association between Melanocortin 4 Receptor Gene Variant and Obesity in Chinese Children and Adolescents
por: Song, Jie-Yun, et al.
Publicado: (2017)

The melanocortin receptors and their accessory proteins
por: Ramachandrappa, Shwetha, et al.
Publicado: (2013)

Quantitative high-throughput assay to measure MC4R-induced intracellular calcium
por: Kumar, Shree Senthil, et al.
Publicado: (2021)

Melanocortin-4 Receptor Gene Mutations in a Group of Turkish Obese Children and Adolescents
por: Tunç, Selma, et al.
Publicado: (2017)

Effect of setmelanotide, a melanocortin‐4 receptor agonist, on obesity in Bardet‐Biedl syndrome
por: Haws, Robert, et al.
Publicado: (2020)

Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations
por: Trier, Cæcilie, et al.
Publicado: (2020)

Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis
por: Xu, Ying, et al.
Publicado: (2021)

OR0302 Regulation Of Human Melanocortin-5 Receptor By Isoforms Of Melanocortin-2 Receptor Accessory Proteins
por: Jiang, Shanshan, et al.
Publicado: (2023)

Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies
por: Rinne, Petteri, et al.
Publicado: (2023)

PSUN97 Regulation of melanocortin-3 and -4 receptors by isoforms of melanocortin-2 receptor accessory protein 1 and 2
por: Ji, Ren-Lei, et al.
Publicado: (2022)

Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling
por: Müller, Anne, et al.
Publicado: (2016)

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective
por: Heyder, Nicolas, et al.
Publicado: (2019)

Peripheral actions and direct central–local communications of melanocortin 4 receptor signaling
por: Li, Lei, et al.
Publicado: (2023)

The E92K Melanocortin 1 Receptor Mutant Induces cAMP Production and Arrestin Recruitment but Not ERK Activity Indicating Biased Constitutive Signaling
por: Benned-Jensen, Tau, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9tde79eh48ke2v4ut38pa3isik