Development and Replication of a Genome-Wide Polygenic Risk Score for Chronic Back Pain

Chronic back pain (CBP) is a complex heritable trait and a major cause of disability worldwide. We developed and validated a genome-wide polygenic risk score (PRS) for CBP using a large-scale GWAS based on UK Biobank participants of European ancestry (N = 265,000). The PRS showed poor overall predic...

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Detalles Bibliográficos
Autores principales: Tsepilov, Yakov A., Elgaeva, Elizaveta E., Nostaeva, Arina V., Compte, Roger, Kuznetsov, Ivan A., Karssen, Lennart C., Freidin, Maxim B., Suri, Pradeep, Williams, Frances M. K., Aulchenko, Yurii S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304922/
https://www.ncbi.nlm.nih.gov/pubmed/37373966
http://dx.doi.org/10.3390/jpm13060977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304922/
https://www.ncbi.nlm.nih.gov/pubmed/37373966
http://dx.doi.org/10.3390/jpm13060977

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