Binding Mechanism of CD47 with SIRPα Variants and Its Antibody: Elucidated by Molecular Dynamics Simulations

The intricate complex system of the differentiation 47 (CD47) and the signal-regulatory protein alpha (SIRPα) cluster is a crucial target for cancer immunotherapy. Although the conformational state of the CD47-SIRPα complex has been revealed through crystallographic studies, further characterization...

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Detalles Bibliográficos
Autores principales: Huang, Kaisheng, Liu, Yi, Wen, Shuixiu, Zhao, Yuxin, Ding, Hanjing, Liu, Hui, Kong, De-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304963/
https://www.ncbi.nlm.nih.gov/pubmed/37375166
http://dx.doi.org/10.3390/molecules28124610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304963/
https://www.ncbi.nlm.nih.gov/pubmed/37375166
http://dx.doi.org/10.3390/molecules28124610

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