Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase

In the search for innovative approaches to cancer chemotherapy, a chemical library of 49 cyanochalcones, 1a-r, 2a-o, and 3a-p, was designed as dual inhibitors of human farnesyltransferase (FTIs) and tubulin polymerization (MTIs) (FTIs/MTIs), two important biological targets in oncology. This approac...

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Detalles Bibliográficos
Autores principales: Zubaș, Andreea, Ghinet, Alina, Farce, Amaury, Dubois, Joëlle, Bîcu, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305003/
https://www.ncbi.nlm.nih.gov/pubmed/37375835
http://dx.doi.org/10.3390/ph16060888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305003/
https://www.ncbi.nlm.nih.gov/pubmed/37375835
http://dx.doi.org/10.3390/ph16060888

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