Exploring Pyrrolo-Fused Heterocycles as Promising Anticancer Agents: An Integrated Synthetic, Biological, and Computational Approach

Five new series of pyrrolo-fused heterocycles were designed through a scaffold hybridization strategy as analogs of the well-known microtubule inhibitor phenstatin. Compounds were synthesized using the 1,3-dipolar cycloaddition of cycloimmonium N-ylides to ethyl propiolate as a key step. Selected co...

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Detalles Bibliográficos
Autores principales: Amărandi, Roxana-Maria, Al-Matarneh, Maria-Cristina, Popovici, Lăcrămioara, Ciobanu, Catalina Ionica, Neamțu, Andrei, Mangalagiu, Ionel I., Danac, Ramona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305032/
https://www.ncbi.nlm.nih.gov/pubmed/37375812
http://dx.doi.org/10.3390/ph16060865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305032/
https://www.ncbi.nlm.nih.gov/pubmed/37375812
http://dx.doi.org/10.3390/ph16060865

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