Cargando…

Exploring Pyrrolo-Fused Heterocycles as Promising Anticancer Agents: An Integrated Synthetic, Biological, and Computational Approach

Five new series of pyrrolo-fused heterocycles were designed through a scaffold hybridization strategy as analogs of the well-known microtubule inhibitor phenstatin. Compounds were synthesized using the 1,3-dipolar cycloaddition of cycloimmonium N-ylides to ethyl propiolate as a key step. Selected co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amărandi, Roxana-Maria, Al-Matarneh, Maria-Cristina, Popovici, Lăcrămioara, Ciobanu, Catalina Ionica, Neamțu, Andrei, Mangalagiu, Ionel I., Danac, Ramona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305032/ https://www.ncbi.nlm.nih.gov/pubmed/37375812 http://dx.doi.org/10.3390/ph16060865

Ejemplares similares

Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives
por: Popovici, Lacramioara, et al.
Publicado: (2019)

Design, Synthesis, Molecular Modelling and Anticancer Activities of New Fused Phenanthrolines
por: Al Matarneh, Cristina Maria, et al.
Publicado: (2020)

Synthesis and Biological Screening of New Cyano-Substituted Pyrrole Fused (Iso)Quinoline Derivatives
por: Al-Matarneh, Maria Cristina, et al.
Publicado: (2021)

Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors
por: Sardaru, Monica-Cornelia, et al.
Publicado: (2020)

Exploring Pyrrolo-Phenanthrolines as Semiconductors for Potential Implementation in Organic Electronics
por: Doroftei, Corneliu, et al.
Publicado: (2023)

Antimycobacterial activity of nitrogen heterocycles derivatives: 7-(pyridine-4-yl)-indolizine derivatives. Part VII(8–12)
por: Olaru, Anda-Mihaela, et al.
Publicado: (2017)

Structural, Electrical and Optical Properties of Pyrrolo[1,2-i][1,7] Phenanthroline-Based Organic Semiconductors
por: Doroftei, Corneliu, et al.
Publicado: (2022)

Benzoquinoline Derivatives: An Attractive Approach to Newly Small Molecules with Anticancer Activity
por: Oniciuc, Liliana, et al.
Publicado: (2023)

Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications
por: Amariucai-Mantu, Dorina, et al.
Publicado: (2020)

Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach
por: Zbancioc, Gheorghita, et al.
Publicado: (2022)

Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy
por: Singh, Sarbjit, et al.
Publicado: (2021)

A Simple Synthesis Route for Selectively Methylated β-Cyclodextrin Using a Copper Complex Sandwich Protecting Strategy
por: Bucur, Stefan, et al.
Publicado: (2021)

Huisgen 3 + n Dipolar Cycloaddition Reactions: An Accessible and Useful Tool in Modern Organic and Heterocycle Synthesis
por: Mangalagiu, Ionel I.
Publicado: (2023)

Seven papers on fused-ring heterocyclic ketones containing an N-tosylpyrrolo[3,4-c]pyrano moiety. Corrigenda
por: Chinnakali, K., et al.
Publicado: (2007)

Heterocycle-Fused Acridines
por: Groundwater, Paul W., et al.
Publicado: (1997)

Huisgen [3 + 2] Dipolar Cycloadditions of Phthalazinium Ylides to Activated Symmetric and Non-Symmetric Alkynes
por: Antoci, Vasilichia, et al.
Publicado: (2020)

Benzoquinoline Chemical Space: A Helpful Approach in Antibacterial and Anticancer Drug Design
por: Lungu, Claudiu N., et al.
Publicado: (2023)

Quinoline–imidazole/benzimidazole derivatives as dual-/multi-targeting hybrids inhibitors with anticancer and antimicrobial activity
por: Diaconu, Dumitrela, et al.
Publicado: (2022)

Cyclodextrin Encapsulated pH Sensitive Dyes as Fluorescent Cellular Probes: Self-Aggregation and In Vitro Assessments
por: Sardaru, Monica-Cornelia, et al.
Publicado: (2020)

The structural diversity of heterocycle-fused potassium cyclopentadienides
por: Nifant'ev, Ilya E., et al.
Publicado: (2019)

Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents
por: Kakkar, Saloni, et al.
Publicado: (2018)

Correction to “Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides”
por: Tokarenko, Anna, et al.
Publicado: (2019)

Synthesis, structure and aromaticity of carborane-fused carbo- and heterocycles
por: Chan, Tek Long, et al.
Publicado: (2018)

Synthesis of Tunable Fluorescent Imidazole-Fused Heterocycle Dimers
por: Zheng, Qiang, et al.
Publicado: (2022)

Synthesis and biological activity of fused tetracyclic Pyrrolo[2,1-c][1,4]benzodiazepines
por: Annor-Gyamfi, Joel K., et al.
Publicado: (2018)

Cytotoxic Evaluation of Some Fused Pyridazino- and Pyrrolo-quinazolinones Derivatives on Melanoma and Prostate Cell Lines
por: Vaseghi, Golnaz, et al.
Publicado: (2017)

Unravelling the synthetic and therapeutic aspects of five, six and fused heterocycles using Vilsmeier–Haack reagent
por: Chahal, Mamta, et al.
Publicado: (2023)

Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets
por: Amewu, Richard Kwamla, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of a Fused Structure of Indolizine and Pyrrolo[1,2-c]pyrimidine: Identification of Its Potent Anticancer Activity against Liver Cancer Cells
por: Nam, Seonghyeon, et al.
Publicado: (2022)

The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles
por: Masdeu, Carme, et al.
Publicado: (2023)

Antimalarial Activity of Highly Coordinative Fused Heterocycles Targeting β-Hematin Crystallization
por: Acosta, María E., et al.
Publicado: (2022)

Ultrasound assisted synthesis of hybrid quinoline-imidazole derivatives: a green synthetic approach
por: Diaconu, Dumitrela, et al.
Publicado: (2021)

Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles
por: Dao-Huy, Toan, et al.
Publicado: (2014)

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues
por: Driowya, Mohsine, et al.
Publicado: (2016)

Development of Heterocycle-Substituted and Fused Azulenes in the Last Decade (2010–2020)
por: Shoji, Taku, et al.
Publicado: (2020)

Convenient Synthesis of N-Heterocycle-Fused Tetrahydro-1,4-diazepinones
por: Dzedulionytė, Karolina, et al.
Publicado: (2022)

Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents
por: Hura, Neha, et al.
Publicado: (2018)

New Synthetic Nitro-Pyrrolomycins as Promising Antibacterial and Anticancer Agents
por: Raimondi, Maria Valeria, et al.
Publicado: (2020)

[3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and Optoelectronics
por: Amariucai-Mantu, Dorina, et al.
Publicado: (2021)

Identification of Spiro-Fused Pyrrolo[3,4-a]pyrrolizines and Tryptanthrines as Potential Antitumor Agents: Synthesis and In Vitro Evaluation
por: Latypova, Diana K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_18tl1dhdlb23h15bqcchov3s1j