Analogs of 6-Bromohypaphorine with Increased Agonist Potency for α7 Nicotinic Receptor as Anti-Inflammatory Analgesic Agents

Hypaphorines, tryptophan derivatives, have anti-inflammatory activity, but their mechanism of action was largely unknown. Marine alkaloid L-6-bromohypaphorine with EC(50) of 80 μM acts as an agonist of α7 nicotinic acetylcholine receptor (nAChR) involved in anti-inflammatory regulation. We designed...

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Detalles Bibliográficos
Autores principales: Ivanov, Igor A., Siniavin, Andrei E., Palikov, Victor A., Senko, Dmitry A., Shelukhina, Irina V., Epifanova, Lyubov A., Ojomoko, Lucy O., Belukhina, Svetlana Y., Prokopev, Nikita A., Landau, Mariia A., Palikova, Yulia A., Kazakov, Vitaly A., Borozdina, Natalia A., Bervinova, Arina V., Dyachenko, Igor A., Kasheverov, Igor E., Tsetlin, Victor I., Kudryavtsev, Denis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305119/
https://www.ncbi.nlm.nih.gov/pubmed/37367693
http://dx.doi.org/10.3390/md21060368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305119/
https://www.ncbi.nlm.nih.gov/pubmed/37367693
http://dx.doi.org/10.3390/md21060368

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