Domperidone Protects Cells from Intoxication with Clostridioides difficile Toxins by Inhibiting Hsp70-Assisted Membrane Translocation

Clostridioides difficile infections cause severe symptoms ranging from diarrhea to pseudomembranous colitis due to the secretion of AB-toxins, TcdA and TcdB. Both toxins are taken up into cells through receptor-mediated endocytosis, autoproteolytic processing and translocation of their enzyme domain...

Descripción completa

Detalles Bibliográficos
Autores principales: Braune-Yan, Maria, Jia, Jinfang, Wahba, Mary, Schmid, Johannes, Papatheodorou, Panagiotis, Barth, Holger, Ernst, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305128/
https://www.ncbi.nlm.nih.gov/pubmed/37368685
http://dx.doi.org/10.3390/toxins15060384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305128/
https://www.ncbi.nlm.nih.gov/pubmed/37368685
http://dx.doi.org/10.3390/toxins15060384

Ejemplares similares