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Domperidone Protects Cells from Intoxication with Clostridioides difficile Toxins by Inhibiting Hsp70-Assisted Membrane Translocation

Clostridioides difficile infections cause severe symptoms ranging from diarrhea to pseudomembranous colitis due to the secretion of AB-toxins, TcdA and TcdB. Both toxins are taken up into cells through receptor-mediated endocytosis, autoproteolytic processing and translocation of their enzyme domain...

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Detalles Bibliográficos
Autores principales:	Braune-Yan, Maria, Jia, Jinfang, Wahba, Mary, Schmid, Johannes, Papatheodorou, Panagiotis, Barth, Holger, Ernst, Katharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305128/ https://www.ncbi.nlm.nih.gov/pubmed/37368685 http://dx.doi.org/10.3390/toxins15060384

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