A VEGFB-Based Peptidomimetic Inhibits VEGFR2-Mediated PI3K/Akt/mTOR and PLCγ/ERK Signaling and Elicits Apoptotic, Antiangiogenic, and Antitumor Activities

Vascular endothelial growth factor receptor 2 (VEGFR2) mediates VEGFA signaling mainly through the PI3K/AKT/mTOR and PLCγ/ERK1/2 pathways. Here we unveil a peptidomimetic (VGB3) based on the interaction between VEGFB and VEGFR1 that unexpectedly binds and neutralizes VEGFR2. Investigation of the cyc...

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Detalles Bibliográficos
Autores principales: Namjoo, Mohadeseh, Ghafouri, Hossein, Assareh, Elham, Aref, Amir Reza, Mostafavi, Ebrahim, Hamrahi Mohsen, Ali, Balalaie, Saeed, Broussy, Sylvain, Asghari, S. Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305181/
https://www.ncbi.nlm.nih.gov/pubmed/37375853
http://dx.doi.org/10.3390/ph16060906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305181/
https://www.ncbi.nlm.nih.gov/pubmed/37375853
http://dx.doi.org/10.3390/ph16060906

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