The Clostridium botulinum C2 Toxin Subunit C2IIa Delivers Enzymes with Positively Charged N-Termini into the Cytosol of Target Cells

The binary Clostridium (C.) botulinum C2 toxin consists of two non-linked proteins. The proteolytically activated binding/transport subunit C2IIa forms barrel-shaped homoheptamers, which bind to cell surface receptors, mediate endocytosis, and translocate the enzyme subunit C2I into the cytosol of t...

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Detalles Bibliográficos
Autores principales: Heber, Sebastian, Borho, Joscha, Stadler, Nicole, Wondany, Fanny, König, Irina, Michaelis, Jens, Papatheodorou, Panagiotis, Barth, Holger, Fellermann, Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305195/
https://www.ncbi.nlm.nih.gov/pubmed/37368691
http://dx.doi.org/10.3390/toxins15060390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305195/
https://www.ncbi.nlm.nih.gov/pubmed/37368691
http://dx.doi.org/10.3390/toxins15060390

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