Recombinant Production, NMR Solution Structure, and Membrane Interaction of the Phα1β Toxin, a TRPA1 Modulator from the Brazilian Armed Spider Phoneutria nigriventer

Phα1β (PnTx3–6) is a neurotoxin from the spider Phoneutria nigriventer venom, originally identified as an antagonist of two ion channels involved in nociception: N-type voltage-gated calcium channel (Ca(V)2.2) and TRPA1. In animal models, Phα1β administration reduces both acute and chronic pain. Her...

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Detalles Bibliográficos
Autores principales: Lyukmanova, Ekaterina N., Mironov, Pavel A., Kulbatskii, Dmitrii S., Shulepko, Mikhail A., Paramonov, Alexander S., Chernaya, Elizaveta M., Logashina, Yulia A., Andreev, Yaroslav A., Kirpichnikov, Mikhail P., Shenkarev, Zakhar O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305275/
https://www.ncbi.nlm.nih.gov/pubmed/37368679
http://dx.doi.org/10.3390/toxins15060378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305275/
https://www.ncbi.nlm.nih.gov/pubmed/37368679
http://dx.doi.org/10.3390/toxins15060378

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