Cargando…

Recombinant Production, NMR Solution Structure, and Membrane Interaction of the Phα1β Toxin, a TRPA1 Modulator from the Brazilian Armed Spider Phoneutria nigriventer

Phα1β (PnTx3–6) is a neurotoxin from the spider Phoneutria nigriventer venom, originally identified as an antagonist of two ion channels involved in nociception: N-type voltage-gated calcium channel (Ca(V)2.2) and TRPA1. In animal models, Phα1β administration reduces both acute and chronic pain. Her...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lyukmanova, Ekaterina N., Mironov, Pavel A., Kulbatskii, Dmitrii S., Shulepko, Mikhail A., Paramonov, Alexander S., Chernaya, Elizaveta M., Logashina, Yulia A., Andreev, Yaroslav A., Kirpichnikov, Mikhail P., Shenkarev, Zakhar O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305275/ https://www.ncbi.nlm.nih.gov/pubmed/37368679 http://dx.doi.org/10.3390/toxins15060378

Ejemplares similares

Mechanisms Involved in the Nociception Triggered by the Venom of the Armed Spider Phoneutria nigriventer
por: Gewehr, Camila, et al.
Publicado: (2013)

Triggering of Protection Mechanism against Phoneutria nigriventer Spider Venom in the Brain
por: Rapôso, Catarina, et al.
Publicado: (2014)

Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors
por: Paramonov, Alexander S., et al.
Publicado: (2020)

An overview of Phoneutria nigriventer spider venom using combined transcriptomic and proteomic approaches
por: Diniz, Marcelo R. V., et al.
Publicado: (2018)

Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors
por: Bychkov, Maxim, et al.
Publicado: (2019)

Gene sequence analysis of toxins from the spider Phoneutria nigriventer revealed an intronless feature
por: Paiva, Ana Luiza Bittencourt, et al.
Publicado: (2020)

New Three-Finger Protein from Starfish Asteria rubens Shares Structure and Pharmacology with Human Brain Neuromodulator Lynx2
por: Paramonov, Alexander S., et al.
Publicado: (2022)

Cell-Free Expression of Sodium Channel Domains for Pharmacology Studies. Noncanonical Spider Toxin Binding Site in the Second Voltage-Sensing Domain of Human Na(v)1.4 Channel
por: Myshkin, Mikhail Yu., et al.
Publicado: (2019)

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer
por: Bychkov, Maxim L., et al.
Publicado: (2021)

Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a
por: Bychkov, Maxim, et al.
Publicado: (2020)

Holistic profiling of the venom from the Brazilian wandering spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics
por: Cardoso, F. C., et al.
Publicado: (2023)

Age-Related Modulations of AQP4 and Caveolin-1 in the Hippocampus Predispose the Toxic Effect of Phoneutria nigriventer Spider Venom
por: Soares, Edilene S., et al.
Publicado: (2016)

Spider toxin inhibits gating pore currents underlying periodic paralysis
por: Männikkö, Roope, et al.
Publicado: (2018)

Vascular Endothelial Growth Factor Increases during Blood-Brain Barrier-Enhanced Permeability Caused by Phoneutria nigriventer Spider Venom
por: Mendonça, Monique C. P., et al.
Publicado: (2014)

Acute Toxicity of the Recombinant and Native Phα1β Toxin: New Analgesic from Phoneutria nigriventer Spider Venom
por: Dallegrave, Eliane, et al.
Publicado: (2018)

Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain
por: Kulbatskii, Dmitrii, et al.
Publicado: (2021)

Intravitreal injection of peptides PnPa11 and PnPa13, derivatives of Phoneutria nigriventer spider venom, prevents retinal damage
por: Dourado, Lays Fernanda Nunes, et al.
Publicado: (2020)

Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors
por: Shenkarev, Zakhar O., et al.
Publicado: (2022)

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2016)

Phoneutria nigriventer Spider Toxin PnTx2-1 (δ-Ctenitoxin-Pn1a) Is a Modulator of Sodium Channel Gating
por: Peigneur, Steve, et al.
Publicado: (2018)

Voltage-Sensing Domain of the Third Repeat of Human Skeletal Muscle NaV1.4 Channel As a New Target for Spider Gating Modifier Toxins
por: Myshkin, M. Yu., et al.
Publicado: (2021)

Expression of VEGF and Flk-1 and Flt-1 Receptors during Blood-Brain Barrier (BBB) Impairment Following Phoneutria nigriventer Spider Venom Exposure
por: Mendonça, Monique C. P., et al.
Publicado: (2013)

Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system
por: Oliveira, Camila Franco Batista, et al.
Publicado: (2019)

δ-Ctenitoxin-Pn1a, a Peptide from Phoneutria nigriventer Spider Venom, Shows Antinociceptive Effect Involving Opioid and Cannabinoid Systems, in Rats
por: Emerich, Bruna Luiza, et al.
Publicado: (2016)

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2023)

Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO/cGMP signaling
por: Nunes, K.P., et al.
Publicado: (2011)

Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer
por: Sudarikova, Anastasia V., et al.
Publicado: (2022)

PnPP-15, a Synthetic Peptide Derived from a Toxin from Phoneutria nigriventer Spider Venom, Alleviates Diabetic Neuropathic Pain and Acts Synergistically with Pregabalin in Mice
por: Mariano, Xavier Maia, et al.
Publicado: (2023)

Comparative venomic profiles of three spiders of the genus Phoneutria
por: Fernandes, Frederico Francisco, et al.
Publicado: (2022)

Analysis of Structural Determinants of Peptide MS 9a-1 Essential for Potentiating of TRPA1 Channel
por: Logashina, Yulia A., et al.
Publicado: (2022)

PnAn13, an antinociceptive synthetic peptide inspired in the Phoneutria nigriventer toxin PnTx4(6–1) (δ-Ctenitoxin-Pn1a)
por: Emerich, Bruna Luiza, et al.
Publicado: (2020)

Human SLURP-1 and SLURP-2 Proteins Acting on Nicotinic Acetylcholine Receptors Reduce Proliferation of Human Colorectal Adenocarcinoma HT-29 Cells
por: Lyukmanova, E. N., et al.
Publicado: (2014)

Cell-free Production of the Extracellular Domain of the Nicotinic Acetylcholine Receptor
por: Lyukmanova, E.N., et al.
Publicado: (2009)

Lipid–Protein Nanodiscs Offer New Perspectives for Structural and Functional Studies of Water-Soluble Membrane-Active Peptides
por: Shenkarev, Z. O., et al.
Publicado: (2014)

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors
por: Lyukmanova, E. N., et al.
Publicado: (2016)

Extracellular Vesicles Derived from Acidified Metastatic Melanoma Cells Stimulate Growth, Migration, and Stemness of Normal Keratinocytes
por: Bychkov, Maxim L., et al.
Publicado: (2022)

Partial Characterization of Venom from the Colombian Spider Phoneutria Boliviensis (Aranae:Ctenidae)
por: Estrada-Gomez, Sebastian, et al.
Publicado: (2015)

Heterologous Expression of an Insecticidal Peptide Obtained from the Transcriptome of the Colombian Spider Phoneutria depilate
por: Vásquez-Escobar, Julieta, et al.
Publicado: (2023)

Orientational Preferences of GPI-Anchored Ly6/uPAR Proteins
por: Zaigraev, Maxim M., et al.
Publicado: (2022)

Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis
por: Bychkov, Maxim L., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4ar8glpofqcavn86tq39098nk6