Design, Synthesis, and Evaluation of the COX-2 Inhibitory Activities of New 1,3-Dihydro-2H-indolin-2-one Derivatives

Thirty-three 1,3-dihydro-2H-indolin-2-one derivatives bearing α, β-unsaturated ketones were designed and synthesized via the Knoevenagel condensation reaction. The cytotoxicity, in vitro anti-inflammatory ability, and in vitro COX-2 inhibitory activity of all the compounds were evaluated. Compounds...

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Detalles Bibliográficos
Autores principales: Pan, Taohua, He, Maofei, Deng, Lulu, Li, Jiang, Fan, Yanhua, Hao, Xiaojiang, Mu, Shuzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305287/
https://www.ncbi.nlm.nih.gov/pubmed/37375225
http://dx.doi.org/10.3390/molecules28124668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305287/
https://www.ncbi.nlm.nih.gov/pubmed/37375225
http://dx.doi.org/10.3390/molecules28124668

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