Preclinical Bioavailability Assessment of a Poorly Water-Soluble Drug, HGR4113, Using a Stable Isotope Tracer

Drug solubility limits intravenous dosing for poorly water-soluble medicines, which misrepresents their bioavailability estimation. The current study explored a method using a stable isotope tracer to assess the bioavailability of drugs that are poorly water-soluble. HGR4113 and its deuterated analo...

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Detalles Bibliográficos
Autores principales: Ha, Eun Ji, Seo, Jeong In, Rehman, Shaheed Ur, Park, Hyung Soon, Yoo, Sang-Ku, Yoo, Hye Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305361/
https://www.ncbi.nlm.nih.gov/pubmed/37376132
http://dx.doi.org/10.3390/pharmaceutics15061684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305361/
https://www.ncbi.nlm.nih.gov/pubmed/37376132
http://dx.doi.org/10.3390/pharmaceutics15061684

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