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Ribosomal DNA Copy Number Variation is Coupled with DNA Methylation Changes at the 45S rDNA Locus

The human ribosomal DNA (rDNA) copy number (CN) has been challenging to analyse, and its sequence has been excluded from reference genomes due to its highly repetitive nature. The 45S rDNA locus encodes essential components of the cell, nevertheless rDNA displays high inter-individual CN variation t...

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Detalles Bibliográficos
Autores principales: Razzaq, Aleem, Bejaoui, Yosra, Alam, Tanvir, Saad, Mohamad, El Hajj, Nady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305490/
https://www.ncbi.nlm.nih.gov/pubmed/37368968
http://dx.doi.org/10.1080/15592294.2023.2229203