Vitamin K-dependent carboxylation regulates Ca(2+) flux and adaptation to metabolic stress in β cells

Vitamin K is a micronutrient necessary for γ-carboxylation of glutamic acids. This post-translational modification occurs in the endoplasmic reticulum (ER) and affects secreted proteins. Recent clinical studies implicate vitamin K in the pathophysiology of diabetes, but the underlying molecular mech...

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Detalles Bibliográficos
Autores principales: Lacombe, Julie, Guo, Kevin, Bonneau, Jessica, Faubert, Denis, Gioanni, Florian, Vivoli, Alexis, Muir, Sarah M., Hezzaz, Soraya, Poitout, Vincent, Ferron, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305719/
https://www.ncbi.nlm.nih.gov/pubmed/37171959
http://dx.doi.org/10.1016/j.celrep.2023.112500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305719/
https://www.ncbi.nlm.nih.gov/pubmed/37171959
http://dx.doi.org/10.1016/j.celrep.2023.112500

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