Cargando…

Vitamin K-dependent carboxylation regulates Ca(2+) flux and adaptation to metabolic stress in β cells

Vitamin K is a micronutrient necessary for γ-carboxylation of glutamic acids. This post-translational modification occurs in the endoplasmic reticulum (ER) and affects secreted proteins. Recent clinical studies implicate vitamin K in the pathophysiology of diabetes, but the underlying molecular mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lacombe, Julie, Guo, Kevin, Bonneau, Jessica, Faubert, Denis, Gioanni, Florian, Vivoli, Alexis, Muir, Sarah M., Hezzaz, Soraya, Poitout, Vincent, Ferron, Mathieu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305719/ https://www.ncbi.nlm.nih.gov/pubmed/37171959 http://dx.doi.org/10.1016/j.celrep.2023.112500

Ejemplares similares

Gamma-carboxylation regulates osteocalcin function
por: Lacombe, Julie, et al.
Publicado: (2015)

VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and Extrahepatic Tissues
por: Lacombe, Julie, et al.
Publicado: (2018)

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans
por: Al Rifai, Omar, et al.
Publicado: (2020)

GGCX and VKORC1 inhibit osteocalcin endocrine functions
por: Ferron, Mathieu, et al.
Publicado: (2015)

Correction: GGCX and VKORC1 inhibit osteocalcin endocrine functions
por: Ferron, Mathieu, et al.
Publicado: (2019)

Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease
por: Berkner, Kathleen L., et al.
Publicado: (2022)

Carboxylative efficacy of trans and cis MK7 and comparison with other vitamin K isomers
por: Cirilli, Ilenia, et al.
Publicado: (2022)

Vitamin K alleviates bone calcium loss caused by Salmonella Enteritidis through carboxylation of osteocalcin
por: Liu, Yaojun, et al.
Publicado: (2021)

K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells
por: Yaron, J R, et al.
Publicado: (2015)

Ca Fluxes in Single Twitch Muscle Fibers
por: Curtis, B. A.
Publicado: (1966)

K Fluxes in Frog Skin
por: Curran, Peter F., et al.
Publicado: (1965)

Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study
por: Hao, Zhenyu, et al.
Publicado: (2020)

The Protein Interaction Network of the Human Transcription Machinery Reveals a Role for the Conserved GTPase RPAP4/GPN1 and Microtubule Assembly in Nuclear Import and Biogenesis of RNA Polymerase II
por: Forget, Diane, et al.
Publicado: (2010)

T2K Replica Target Hadron Production Measurements in NA61/SHINE and T2K Neutrino Flux Predictions
por: Hasler, Alexis
Publicado: (2015)

Shaped by leaky ER: Homeostatic Ca(2+) fluxes
por: Schulte, Annemarie, et al.
Publicado: (2022)

Absence of Vitamin K-Dependent γ-Carboxylation in Human Periostin Extracted from Fibrotic Lung or Secreted from a Cell Line Engineered to Optimize γ-Carboxylation
por: Annis, Douglas S., et al.
Publicado: (2015)

Na and K Fluxes in Nitella clavata
por: Barr, Charles E.
Publicado: (1965)

T2K neutrino flux prediction
por: Abe, K., et al.
Publicado: (2012)

A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity
por: Cloutier, Philippe, et al.
Publicado: (2013)

Ca2+ fluxes and channel regulation in rods of the albino rat
Publicado: (1996)

Signal transduction mechanisms involved in hormonal Ca2+ fluxes.
por: Williamson, J R, et al.
Publicado: (1990)

Bioluminescent Sensors for Ca(++) Flux Imaging and the Introduction of a New Intensity-Based Ca(++) Sensor
por: Yang, Jie, et al.
Publicado: (2021)

Hydrogen Peroxide-Induced Root Ca(2+) and K(+) Fluxes Correlate with Salt Tolerance in Cereals: Towards the Cell-Based Phenotyping
por: Wang, Haiyang, et al.
Publicado: (2018)

Characterization of the Flux System: Lithium-Aluminum Silicate (Li)–Alkali Feldspars (Na,K); Magnesium (Mg) and Calcium (Ca)–Silicates
por: Stempkowska, Agata
Publicado: (2021)

Vitamin K-Dependent Carboxylation of Osteocalcin in Bone—Ally or Adversary of Bone Mineral Status in Rats with Experimental Chronic Kidney Disease?
por: Ziemińska, Marta, et al.
Publicado: (2022)

Properties of chloride-stimulated 45Ca flux in skinned muscle fibers
Publicado: (1978)

Major vacuolar TPC1 channel in stress signaling: what matters, K(+), Ca(2+) conductance or an ion-flux independent mechanism?
por: Pottosin, Igor, et al.
Publicado: (2022)

Vitamin K Metabolism and Vitamin K-Dependent Proteins
por: Levinson, Barry L.
Publicado: (1980)

Hadron Production Measurements in NA61/SHINE for the Precise T2K Neutrino Flux Prediction and the Cosmic ray Physics Program
por: Häsler, Alexis
Publicado: (2015)

Deoxygenative trifluoromethylthiolation of carboxylic acids
por: Mao, Runze, et al.
Publicado: (2019)

Salinomycin inhibits cholangiocarcinoma growth by inhibition of autophagic flux
por: Klose, Johannes, et al.
Publicado: (2017)

Ca(V)β-subunit dependence of forward and reverse trafficking of Ca(V)1.2 calcium channels
por: Ferron, Laurent, et al.
Publicado: (2022)

Phenotypic Characterization of MIP-CreERT(1Lphi) Mice With Transgene-Driven Islet Expression of Human Growth Hormone
por: Oropeza, Daniel, et al.
Publicado: (2015)

Dishevelled activates Ca(2+) flux, PKC, and CamKII in vertebrate embryos
por: Sheldahl, Laird C., et al.
Publicado: (2003)

Calcium Release Flux Underlying Ca(2+) Sparks of Frog Skeletal Muscle
por: Ríos, Eduardo, et al.
Publicado: (1999)

Na+- and cGMP-induced Ca2+ fluxes in frog rod photoreceptors
Publicado: (1987)

Mitochondrial Ca(2+) flux modulates spontaneous electrical activity in ventricular cardiomyocytes
por: Xie, An, et al.
Publicado: (2018)

Endoplasmic Reticulum–Mitochondrial Ca(2+) Fluxes Underlying Cancer Cell Survival
por: Ivanova, Hristina, et al.
Publicado: (2017)

Ca(2+) Flux: Searching for a Role in Efferocytosis of Apoptotic Cells in Atherosclerosis
por: Tajbakhsh, Amir, et al.
Publicado: (2019)

Down-Regulation of Ca(2+)-Activated K(+) Channel K(Ca)1.1 in Human Breast Cancer MDA-MB-453 Cells Treated with Vitamin D Receptor Agonists
por: Khatun, Anowara, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7niffrv8d5dqua886kkrhb2ra8