The ACE2 receptor accelerates but is not biochemically required for SARS-CoV-2 membrane fusion

The SARS-CoV-2 coronavirus infects human cells via the ACE2 receptor. Structural evidence suggests that ACE2 may not just serve as an attachment factor but also conformationally activate the SARS-CoV-2 spike protein for membrane fusion. Here, we test that hypothesis directly, using DNA-lipid tetheri...

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Detalles Bibliográficos
Autores principales: Cervantes, Marcos, Hess, Tobin, Morbioli, Giorgio G., Sengar, Anjali, Kasson, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306070/
https://www.ncbi.nlm.nih.gov/pubmed/37389252
http://dx.doi.org/10.1039/d2sc06967a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306070/
https://www.ncbi.nlm.nih.gov/pubmed/37389252
http://dx.doi.org/10.1039/d2sc06967a

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